The main objective of this part of the Trisk programme is to obtain experience in performing in-depth toxicological risk assessment. This will be done either at recognised institutions performing toxicological risk assessments as their daily activity, or in the form of in-house training (i.e. in the institution where the trainees are employed). The purpose is that the trainees acquire hands-on experience in following the consecutive steps in the complete toxicological risk assessment process. A complete risk assessment will at least include: collection and collation of data from the appropriate experiments, an assessment of the exposure scenarios, the interpretation of the hazard identification, hazard characterization, and a motivated weighing of the exposure vs. the hazard, concluding in an overall assessment of the risk and should include a proposal of a health-based guidance value. This will have to result in a complete risk assessment report that may be the subject of external reviewing

During the applied training trainees will spend at least 450 hours in an environment where toxicological risk assessment is performed as one of the major tasks. Trainees will become familiar with the practical work of performing risk assessments and with the different steps involved in the process. Essential for a successful training period is that the trainees will become able to collect and collate data on the different aspects, e.g. ranging from the physico-chemical properties of the compound or product under study, experimental toxicological data (in vivo, in vitro), exposure, etc. Trainees need to learn to judge the quality of the collected data and to integrate these in a complete risk assessment.

The aim of this part of the programme is that the trainee shows that she/he is able to independently perform an in-depth risk assessment, integrating the different elements of the process, and report on it in a written and verbal form.

This part of the Trisk programme will be coordinated and administrated by IRAS-UU. The final decision on where a trainee will perform this training is taken by the coordinator.

Contact: Prof Dr Bas J. Blaauboer or Ms. Ingrid Dahmen
Institute for Risk Assessment Sciences, Division of Toxicology
Utrecht University
PO Box 80.177, 3508 TD Utrecht
The Netherlands
Tel. +31-30-253-9494 or 5330
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